HCID 67015665, compound → HCID 67015694, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (R)-1-(2-methylpyridin-4-yl)-3-phenyl-3-o-tolylpropan-1-ol (110 mg, 347 mmol), and manganese dioxide (121 mg, 1.39 mmol) in toluene (2 mL) was heated at 90° C. for 3 h, then filtered through diatomaceous earth and concentrated in vacuo. Chromatography (silica gel, 10 g, 10% to 50% ethyl acetate in heptane) produced the title compound (60 mg, 55%). White semisolid, MS (ESI+): m/z=316.3 ([M+H]+).

Provenance & Evidence