Trifluoroacetic anhydride → HCID 136167040, compound

Participants

Reaction Steps

Trifluoroacetic anhydride (421 mg, 2.01 mmol) was added at 0° C. to a suspension of (R,E)-4-(3-(4-(4-carboxypiperidin-1-yl)phenyl)-1-(hydroxyimino)-3-o-tolylpropyl)-2-methyl-pyridine 1-oxide (95 mg, 201 μmol) in dichloromethane (3 mL) to give a white suspension, then after 1 h another portion of trifluoroacetic anhydride (421 mg, 2.01 mmol) was added. The reaction mixture was allowed to reach room temperature over 1 h, then treated with 1 M aq. sodium hydroxide solution and stirred for another 90 min. After extraction with dichloromethane, the organic layer was washed with brine, dried over sodium sulfate, filtered, and evaporated. The residue was purified by preparative HPLC to produce the title compound (13 mg, 14%). Light yellow oil, MS (ESI+): m/z=474.4 ([M+H]+).

Provenance & Evidence