Hydrochloric Acid → HCID 136167009, compound

Participants

Reaction Conditions

Reaction Steps

Hydrogen chloride solution (4 M in 1,4-dioxane, 0.22 mL, 0.88 mmol) was added to a solution of (R,E)-tert-butyl 4-(4-(3-(hydroxyimino)-3-(2-methylpyridin-4-yl)-1-o-tolylpropyl)-phenyl)-5,6-dihydropyridine-1(2H)-carboxylate (45 mg, 87.9 μmol) in 1,4-dioxane (4 mL). The reaction mixture was heated for 17 h at 50° C., then treated with sat. aq. sodium hydrogen-carbonate solution (4 mL) and partitioned between sat. aq. ammonium chloride solution and ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, filtered, and evaporated. The crude material was triturated with ethyl acetate to afford the title compound (20 mg, 55%). Off-white solid, MS (ESI+): m/z=412.4 ([M+H]+).

Provenance & Evidence