Lithium hydroxide, monohydrate → HCID 58043191, compound

Participants

Reaction Steps

To a solution of (E)-methyl 3-(4′-(1-(4-fluoro-2-methylphenyl)-3-(3-methoxy-3-oxopropanoyloxyimino)-3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)propyl)biphenyl-4-ylamino)-3-oxopropanoate (0.044 g, 67.1 μmol, from example 399) in dioxane (1 mL) and water (1 mL) was added lithium hydroxide monohydrate (7.04 mg, 168 μmol). The resulting clear solution was stirred at room temperature for 2.25 hours, and then the solvents were removed. The residue was dissolved in water (2 mL) and the pH of the solution was adjusted to approximately to pH 3 using 1M aqueous hydrochloric acid. The resulting suspension was filtered, washed with water and the filter cake dried in high vacuum. Colourless solid (0.023 g, 63%). MS (ESI+): m/z=542.2 ([M+H]+).

Provenance & Evidence