4-Carboxyphenylboronic Acid → HCID 58043365, compound

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The title compound was prepared in analogy to example 166, from 5-{3-(4-bromo-phenyl)-3-(2,4-difluoro-phenyl)-1-[(E)-hydroxyimino]-propyl}-1-methyl-1H-pyridin-2-one (example 402) and 4-carboxyphenylboronic acid (CAS RN 14047-29-1). The compound was purified by two silica gel chromatographies using a 20 g column and a MPLC system eluting with a gradient of dichloromethane:methanol (100:0 to 70:30). Light brown foam. MS (ESI+): m/z=489.2 ([M+H]+).

Provenance & Evidence