Sulfamide → HCID 66666614, compound

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Reaction Steps

A solution of (R)-3-(4-chloro-2-methylphenyl)-1-(2-methylpyridin-4-yl)-3-(4-(piperidin-4-yl)phenyl)propan-1-one (60 mg, 0.14 mmol) and sulfamide (20 mg, 0.21 mmol) in 1,4-dioxane (5 mL) was stirred for 17 h at 108° C., then partitioned between sat. aq. ammonium chloride solution and ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, filtered, and evaporated. Flash chromatography (silica gel, 50% to 100% EtOAc in heptane) afforded the title compound (59 mg, 83%). White foam, MS (ESI+): m/z=512.3 ([M+H]+).

Provenance & Evidence