5-Bromo-2-methoxypyridine → (S)-3-(4-Bromophenyl)-1-(6-methoxypyridin-3-yl)-3-o-tolylpropan-1-one

Participants

Role	Name	HCID	Charge
Reactant	5-Bromo-2-methoxypyridine	HCID 2734895	—
Reactant	(S)-3-(4-bromophenyl)-N-methoxy-N-methyl-3-o-tolylpropanamide	HCID 71813343	—
Reactant	Butyllithium	HCID 178418339	—
Product	(S)-3-(4-Bromophenyl)-1-(6-methoxypyridin-3-yl)-3-o-tolylpropan-1-one	HCID 67015766	—

Reaction Steps

In analogy to example 151, step 1, 5-bromo-2-methoxypyridine was reacted first with n-butyllithium and later with (S)-3-(4-bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide (example 142, step 1) to give the title compound as a colourless oil, MS (ESI+): m/z=410.1 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08765730B2
Source dataset	uspto-grants-2014_07
ORD ID	ord-c487af98d3374414870062d59d35f5b1
Source note	uspto-grants-2014_07