HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-[(S)-3-(4-Bromo-phenyl)-3-o-tolyl-propionyl]-1H-pyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (S)-3-(4-Bromophenyl)-1-(6-methoxypyridin-3-yl)-3-o-tolylpropan-1-one | HCID 67015766 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-[(S)-3-(4-Bromo-phenyl)-3-o-tolyl-propionyl]-1H-pyridin-2-one | HCID 67015825 | — |
Reaction Steps
In analogy to example 162, step 2, (S)-3-(4-bromophenyl)-1-(6-methoxypyridin-3-yl)-3-o-tolyl-propan-1-one was reacted with 37% aqueous hydrochloric acid solution in 1,4-dioxane to give the title compound as a light yellow foam, MS (ESI+): m/z=396.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-a7b7b6622abc4dc4879f037c5afba266 |
| Source note | uspto-grants-2014_07 |