Hydrochloric Acid → HCID 58043182, compound

Participants

Reaction Steps

(R,E)-tert-Butyl 4-(4-(3-(hydroxyimino)-3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1-o-tolylpropyl)phenyl)piperidine-1-carboxylate (example 506, 30 mg) was dissolved in ethanol (0.8 mL) and hydrochloric acid solution (4.0 M in 1,4-dioxane (170 μl, 680 μmol) was added, then after 14 h the reaction mixture was poured onto aq. sat. sodium hydrogencarbonate solution and extracted 2 times with dichloromethane. The combined organic layers were washed with brine dried over magnesium sulfate, filtered and evaporated. The residue was triturated with ethyl acetate/heptane to afford the title compound (12 mg, 41%). Light yellow solid; MS (ESI+): m/z=: 430.5 [M+H]+).

Provenance & Evidence