Methylamine → 2-Methylamino-N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-acetamide

Participants

Reaction Steps

To a stirred suspension of 2-chloro-N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-acetamide (XXIV, Lg=Cl) (150 mg, 0.52 mmol) in dimethylformamide (1.4 mL), a 33% solution of methylamine in ethanol was added (9 mL, 72 mmol). The reaction mixture was stirred at room temperature for 3 hours. The ethanol was then evaporated under reduced pressure and the mixture was diluted with diethyl ether and filtered. A light-yellow solid was then collected, washed with diethyl ether then with cold water and dried. 2-Methylamino-N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-acetamide was obtained in moderate yield (100 mg, 68%).

Provenance & Evidence