1-Chloro-4-hydroxyisoquinoline-3-carboxylic acid → 2-[(1-Chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-2-methyl-propionic acid

HRID 1618132Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1618132
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[C:4]([C:13]([OH:15])=O)[N:3]=1.Cl.C[O:18][C:19](=[O:24])[C:20]([NH2:23])([CH3:22])[CH3:21]>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[C:4]([C:13]([NH:23][C:20]([CH3:22])([CH3:21])[C:19]([OH:24])=[O:18])=[O:15])[N:3]=1

Komponenten

3

Edukt 2

HCID 110205201-Chloro-4-hydroxyisoquinoline-3-carboxylic acidHCID 13258034Methyl 2-aminoisobutyrate hydrochloride

Produkt 1

HCID 114497052-[(1-Chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-2-methyl-propionic acid

Versuchsvorschrift

Prepared in analogy to Example A-1 a) and b) from 1-chloro-4-hydroxy-isoquinoline-3-carboxylic acid from Example A-2 d) and 2-amino-2-methyl-propionic acid methyl ester hydrochloride; MS-(+)-ion: M+1=308.9 amu.

Quellen und Nachweise

ORD-Eintrag
ord-340e6a79f9ea4611bb6ba90601bd62c7
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08765956B2

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