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Methyl D-alaninate hydrochloride → (6-Benzyloxy-1-chloro-4-hydroxy-isoquinoline-3-carbonyl-amino]-propionic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl D-alaninate hydrochloride | HCID 11182647 | — |
| 反応物 | 6-Benzyloxy-1-chloro-4-hydroxy-isoquinoline-3-carboxylic acid | HCID 18698135 | — |
| 生成物 | (6-Benzyloxy-1-chloro-4-hydroxy-isoquinoline-3-carbonyl-amino]-propionic acid methyl ester | HCID 86608140 | — |
反応手順
6-Benzyloxy-1-chloro-4-hydroxy-isoquinoline-3-carboxylic acid, 0.33 g, was coupled with D-Alanine methyl ester hydrochloride, 0.150 g, analogously to Example A-1a). 0.205 g of off-white, solid product were obtained, MS-(+)-ion, M+1=415.0 amu.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08765956B2 |
| 出典データセット | uspto-grants-2014_07 |
| ORD ID | ord-9c3c2a84a668470bb9fd3ce9fba17171 |
| 出典メモ | uspto-grants-2014_07 |