Glycine → [(1-Bromo-4-hydroxy-7-phenylsulfanyl-isoquinoline-3-carbonyl)-amino]-acetic acid

Participants

Reaction Steps

216 mg of 1-bromo-4-hydroxy-7-phenylsulfanyl-isoquinoline-3-carboxylic acid butyl ester (0.5 mmol) from Example D-1 e) were reacted with glycine and sodium methylate analogously to Example D-1 g). 192 mg of the title compound were obtained; 1H NMR (DMSO-d6): δ=9.15 (t, 1H), 8.22 (d, 1H), 7.52 to 7.74 (m, 7 H), 4.01 (d, 2 H).

Provenance & Evidence