Diisopropylethylamine → 4-(4-(1-(4-(2-(1-methylethylsulfonamido)-2-oxoethoxy)phenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)-N-((1-(pyrrolidin-1-ylmethyl)cyclopropyl)methyl)benzamide

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Reaction Steps

2-(4-(1-(4-(4-((1-(pyrrolidin-1-ylmethyl)cyclopropyl)methylcarbamoyl)phenylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)cyclopropyl)phenoxy)acetic acid (20 mg, 0.031 mmol), propane-2-sulfonamide (4.88 mg, 0.040 mmol), PyBOP (23.81 mg, 0.046 mmol), and Hunig's Base (0.027 mL, 0.153 mmol) were stirred in DCM (Volume: 3 mL) for 3 days. The solvent was removed and the crude material was purified by Prep-HPLC (Column: Sunfire prep C18 OBO 5 uM, 30×100 mm by Waters Corp) using a gradient of 10-60% ACN/water w/0.1% TFA modifier to give 4-(4-(1-(4-(2-(1-methylethylsulfonamido)-2-oxoethoxy)phenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)-N-((1-(pyrrolidin-1-ylmethyl)cyclopropyl)methyl)benzamide (5 mg). 1H NMR (500 MHz, MeOD) δ ppm 0.75 (s, 2H), 0.83 (s, 2H), 1.14-1.42 (m, 10H), 2.12-2.26 (m, 4H), 3.06-3.43 (m, 7H), 3.77-3.88 (m, 2H), 4.64 (s, 2H), 4.81-4.92 (m, 2H), 6.86-7.00 (m, 2H), 7.21-7.32 (m, 2H), 7.64-7.76 (m, 3H), 7.89 (s, 1H); LC-MS (Condition A), MS m/z (M++H) 761.2.

Provenance & Evidence