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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1618412Generated: November 3, 2026

Cyclopropylacetylene → HCID 87082348, compound

https://huagongshe.com/reaction/1618412

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclopropylacetyleneHCID 138823—
ReactantN-(3-(3-bromophenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamideHCID 57608426—
ProductHCID 87082348HCID 87082348—

Reaction Steps

Sonogashira reaction of 25 with ethynylcyclopropane yielded N-(3-(3-(2-cyclopropylethynyl)phenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamide as dark brown oil. Yield (0.8 g, 83%). This used without further purification in the next transformation.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08766007B2
Source datasetuspto-grants-2014_07
ORD IDord-c926c669083a46e08ea82f5d17ea422e
Source noteuspto-grants-2014_07