Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Quinoline | HCID 7047 | — |
| Reactant | Indoline | HCID 10328 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 34500-40-8 | HCID 3771305 | — |
Reaction Steps
A mixture of indoline (1 eq), quinoline (2 eq), cesium carbonate (2 eq), Pd2(dba)3 (0.1 eq) and (±) BINAP (0.15 eq) were dissolved in 1,4-dioxane (0.4M). The resulting mixture was purged with argon and subjected to microwave heating at 140° C. for 3 h. The crude residue was purified by chromatography to give the desired morpholino-quinoline product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08765940B2 |
|---|
| Source dataset | uspto-grants-2014_07 |
|---|
| ORD ID | ord-40aceeab2af24e50952e65f0770eeae2 |
|---|
| Source note | uspto-grants-2014_07 |
|---|
