HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Tributylstannyl)pyridine → 4-Chloro-8-fluoro-3-methyl-2-(pyridin-2-yl)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Tributylstannyl)pyridine | HCID 607784 | — |
| Reactant | 2,4-Dichloro-8-fluoro-3-methylquinoline | HCID 59631031 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-Chloro-8-fluoro-3-methyl-2-(pyridin-2-yl)quinoline | HCID 59631358 | — |
Reaction Steps
Prepared according to procedure E using 2,4-dichloro-8-fluoro-3-methylquinoline (1.0 g, 4.35 mmol), Pd(PPh3)4 (251 mg, 0.22 mmol) and 2-tributylstannylpyridine (1.6 mL, 4.35 mmol) in toluene (15 mL) to give 4-chloro-8-fluoro-3-methyl-2-(pyridin-2-yl)quinoline as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765940B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-7ec9ba6b8859457f87d0add0eb64c117 |
| Source note | uspto-grants-2014_07 |