HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Dimethyl 2-(5-bromo-3-nitropyridin-2-YL)malonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Dimethyl malonate | HCID 7943 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Bromo-2-chloro-3-nitropyridine | HCID 7019412 | — |
| Product | Dimethyl 2-(5-bromo-3-nitropyridin-2-YL)malonate | HCID 53217420 | — |
Reaction Steps
Prepared according to procedure G using 5-bromo-2-chloro-3-nitropyridine (25 g, 105 mmol) and potassium carbonate (44 g, 316 mmol), dimethyl malonate (18 mL, 158 mmol) in DMF (105 mL, 105 mmol). After purification dimethyl 2-(5-bromo-3-nitropyridin-2-yl)malonate was obtained as a dark liquid. Mass Spectrum (ESI) m/e=333 [(M+1) (79Br)] and 335 [(M+1) (81Br)].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765940B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-f33eb5674523432091dd39ee36f53bec |
| Source note | uspto-grants-2014_07 |