HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1618512Generated: November 1, 2026
Hydrochloric Acid → 7-Fluoro-4-(6-iodo-3,3-dimethylindolin-1-yl)-3-methyl-2-(pyridin-2-yl)quinoline
https://huagongshe.com/reaction/1618512
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 6-Iodo-3,3-dimethylindoline | HCID 58221307 | — |
| Reactant | 4-Chloro-7-fluoro-3-methyl-2-(pyridin-2-yl)quinoline | HCID 59631075 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 7-Fluoro-4-(6-iodo-3,3-dimethylindolin-1-yl)-3-methyl-2-(pyridin-2-yl)quinoline | HCID 67284898 | — |
Reaction Steps
Prepared according to procedure L using 4-chloro-7-fluoro-3-methyl-2-(pyridin-2-yl)quinoline (250 mg, 0.92 mmol), 6-iodo-3,3-dimethylindoline (250 mg, 0.92 mmol) and 4.0M solution of HCl in 1,4-dioxane (0.22 mL, 0.92 mmol) in NMP (1.0 mL) and heating at 150° C. for 3 h in the microwave. After purification 7-fluoro-4-(6-iodo-3,3-dimethylindolin-1-yl)-3-methyl-2-(pyridin-2-yl)quinoline was obtained as a foam. Mass Spectrum (ESI) m/e=510 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08765940B2 |
|---|
| Source dataset | uspto-grants-2014_07 |
|---|
| ORD ID | ord-19e8ff0fde9646c4a42a77b896b27f63 |
|---|
| Source note | uspto-grants-2014_07 |
|---|
