Pyridine → HCID 59631403, compound

HRID 1618516Notes

Reaction equation

HRID 1618516 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].N1C=CC=CC=1.[CH:15]([CH:18]([C:24](OCC)=[O:25])[C:19]([O:21][CH2:22][CH3:23])=[O:20])([CH3:17])[CH3:16]>>[F:1][C:2]1[CH:3]=[C:4]([NH:5][C:24]([CH:18]([CH:15]([CH3:16])[CH3:17])[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[O:25])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 1049PyridineHCID 97423-FluoroanilineHCID 12966Diethyl isopropylmalonate

Product 1

HCID 59631403HCID 59631403, compound

Procedure

Prepared according to procedure A using 3-fluoroaniline (8.70 mL, 90 mmol), pyridine (10.92 mL, 135 mmol) and diethyl isopropylmalonate (20.02 mL, 99 mmol). The crude was purified by column chromatography (hexane:EtOAc, 1:0 to 4:1) to give ethyl 2-(3-fluorophenylcarbamoyl)-3-methylbutanoate.

Workup

  1. customPrepared
  2. customThe crude was purified by column chromatography (hexane:EtOAc, 1:0 to 4:1)

Sources & evidence

ORD record
ord-e3c780e9512d4786a59fca443b548dac
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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