Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Diethyl methylmalonate | HCID 11857 | — |
| Reactant | 3,5-Difluoroaniline | HCID 96595 | — |
| Product | HCID 59631396 | HCID 59631396 | — |
Reaction Steps
Prepared according to procedure A using diethyl 2-methylmalonate (34.5 mL, 205 mmol), pyridine (15.6 mL, 190 mmol), and 3,5-difluorobenzenamine (12.4 g, 96 mmol). The reaction was heated to 130° C. for 2 days. Purification afforded ethyl 3-(3,5-difluorophenylamino)-2-methyl-3-oxopropanoate. Mass Spectrum (ESI) m/e=258 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08765940B2 |
|---|
| Source dataset | uspto-grants-2014_07 |
|---|
| ORD ID | ord-6e5ba085c8b04f2b9132b7e542d8485d |
|---|
| Source note | uspto-grants-2014_07 |
|---|
