2-(Tributylstannyl)pyridine → 4-Chloro-7-fluoro-2-(pyridin-2-yl)quinoline-3-carbonitrile

Participants

Reaction Conditions

Reaction Steps

Prepared according to procedure E using 2,4-dichloro-7-fluoroquinoline-3-carbonitrile (230 mg, 0.95 mmol) (described herein), 2-(tributylstannyl)pyridine (0.42 mL, 1.15 mmol), tetrakis(triphenylphosphine)palladium(o) (110 mg, 0.095 mmol), and toluene (4.1 mL). The reaction mixture was stirred at 100° C. for 18 h, and subsequent purification afforded 4-chloro-7-fluoro-2-(pyridin-2-yl)quinoline-3-carbonitrile as an off-white solid. Mass Spectrum (ESI) m/e=284 (M+1).

Provenance & Evidence