Piperidine → 4-Chloro-5,7-difluoro-3-methyl-2-(piperidin-1-yl)quinoline

Participants

Reaction Conditions

Reaction Steps

The 2,4-dichloro-5,7-difluoro-3-methylquinoline (300 mg, 1.21 mmol) was dissolved in isopropanol (3 mL) and piperidine (0.120 mL, 1.21 mmol) was added to the sealed tube. The mixture was heated to 85° C. and stirred overnight. The reaction was then cooled and concentrated to dryness. The residue was then purified by medium pressure chromatography (silica, 0 to 40% DCM:hexane) to give 4-chloro-5,7-difluoro-3-methyl-2-(piperidin-1-yl)quinoline. Mass Spectrum (ESI) m/e=297.1 (M+1).

Provenance & Evidence