Ethyl 2-methylacetoacetate → HCID 178486796, compound

HRID 1618578Notes

Reaction equation

HRID 1618578 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][C:9]=1[CH3:10])[NH2:6].C([O:13][C:14](=O)[CH:15]([CH3:19])[C:16]([CH3:18])=O)C>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:7]([C:14]([OH:13])=[C:15]([CH3:19])[C:16]([CH3:18])=[N:6]2)=[CH:8][C:9]=1[CH3:10]

Participants

3

Reactant 2

HCID 701Ethyl 2-methylacetoacetateHCID 278823-Methoxy-4-methylaniline

Product 1

HCID 178486796HCID 178486796, compound

Procedure

Prepared according to procedure R using 3-methoxy-4-methylaniline (617.8 mg, 4.5 mmol), ethyl-2-methyl-acetoacetate (1.3 mL, 9.1 mmol), and PPA (1.87 g, 18.7 mmol) to give 7-methoxy-2,3,6-trimethylquinolin-4-ol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-1516ab72a2e942b886ce776e9cb52dd9
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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