6-Iodo-3,3-dimethylindoline → 6-Chloro-4-(6-iodo-3,3-dimethylindolin-1-yl)-2,3-dimethylquinoline

HRID 1618588Notes

Reaction equation

HRID 1618588 reaction equation
[I:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:12])([CH3:11])[CH2:7][NH:8]2)=[CH:4][CH:3]=1.Cl[C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([Cl:24])[CH:22]=2)[N:17]=[C:16]([CH3:25])[C:15]=1[CH3:26]>>[Cl:24][C:21]1[CH:22]=[C:23]2[C:18](=[CH:19][CH:20]=1)[N:17]=[C:16]([CH3:25])[C:15]([CH3:26])=[C:14]2[N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([I:1])[CH:10]=2)[C:6]([CH3:12])([CH3:11])[CH2:7]1

Participants

3

Reactant 2

HCID 582213076-Iodo-3,3-dimethylindolineHCID 609949634,6-Dichloro-2,3-dimethylquinoline

Product 1

HCID 672846176-Chloro-4-(6-iodo-3,3-dimethylindolin-1-yl)-2,3-dimethylquinoline

Procedure

Prepared according to procedure M using 6-iodo-3,3-dimethylindoline (0.604 g, 2.21 mmol) and 4,6-dichloro-2,3-dimethylquinoline (0.5 g, 2.21 mmol) to give 6-chloro-4-(6-iodo-3,3-dimethylindolin-1-yl)-2,3-dimethylquinoline as a brown solid: Mass Spectrum (ESI) m/e=463.0 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-658f1cdf1a9a46fbb56ec9bc8670d2ad
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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