4,6-Dichloro-2,3-dimethylquinoline → 4-(6-chloro-2,3-dimethyl-4-quinolinyl)-6-(4-morpholinyl)-3,4-dihydro-2H-1,4-benzoxazine

Participants

Reaction Steps

Prepared according to procedure T using 6-morpholino-3,4-dihydro-2H-benzo-[b][1,4]oxazine (0.1 g, 0.454 mmol) and 4,6-dichloro-2,3-dimethylquinoline (0.2053 g, 0.908 mmol) to give 4-(6-chloro-2,3-dimethyl-4-quinolinyl)-6-(4-morpholinyl)-3,4-dihydro-2H-1,4-benzoxazine as a yellow solid: 1H NMR (500 MHz, DMSO-d6) δ ppm 8.01 (1H, d, J=9.5 Hz), 7.64-7.73 (2H, m), 6.77 (1H, d, J=8.6 Hz), 6.22 (1H, dd, J=8.7, 2.6 Hz), 5.41 (1H, d, J=2.7 Hz), 4.26-4.47 (2H, m), 3.57-3.67 (2H, m), 3.47-3.55 (4H, m), 2.69 (3H, s), 2.60-2.66 (4H, m), 2.22 (3H, s); Mass Spectrum (ESI) m/e=410.2 (M+1).

Provenance & Evidence