4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → 1-(6-chloro-2,3-dimethyl-4-quinolinyl)-6-(4-pyridinyl)-1H-indole-4-carbonitrile

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Reaction Steps

Prepared according to procedure W using 6-bromo-1-(6-chloro-2,3-dimethylquinolin-4-yl)-1H-indole-4-carbonitrile (0.2 g, 0.243 mmol) and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (0.06 g, 0.292 mmol) to give 1-(6-chloro-2,3-dimethyl-4-quinolinyl)-6-(4-pyridinyl)-1H-indole-4-carbonitrile as a: 1H NMR (400 MHz, DMSO-d6) δ ppm 8.55 (2H, d, J=5.9 Hz), 8.22 (1H, d, J=1.2 Hz), 8.12 (1H, d, J=9.0 Hz), 8.01 (1H, d, J=3.1 Hz), 7.70-7.79 (4H, m), 7.11 (1H, d, J=3.1 Hz), 6.91 (1H, d, J=2.3 Hz), 2.78 (3H, s), 2.02 (3H, s); Mass Spectrum (ESI) m/e=409.1 (M+1).

Provenance & Evidence