Ethyl 2-methylacetoacetate → HCID 178432239, compound

HRID 1618632Notes

Reaction equation

HRID 1618632 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH2:5].[CH3:12][CH:13]([C:19](=O)[CH3:20])[C:14](OCC)=[O:15]>>[CH3:20][C:19]1[C:13]([CH3:12])=[C:14]([OH:15])[C:6]2[C:4](=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:9]=[CH:8][CH:7]=2)[N:5]=1

Participants

3

Reactant 2

HCID 701Ethyl 2-methylacetoacetateHCID 69222-(Trifluoromethyl)aniline

Product 1

HCID 178432239HCID 178432239, compound

Procedure

Prepared according to procedure R using 2-(trifluoromethyl)aniline (1.61 g, 10 mmol) and ethyl 2-methyl-3-oxobutanoate (2.89 g, 20 mmol) in PPA (4 g, 40 mmol). The resulting precipitate was collected by filtration, washed with water, and dried to give 2,3-dimethyl-8-(trifluoromethyl)quinolin-4-ol. Mass Spectrum (ESI) m/e=242 (M+1).

Workup

  1. customPrepared
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-fb51ccdeec35494790c1662dec935cfd
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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