2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl → HCID 67285611, compound

Participants

Reaction Steps

Prepared according to procedure Y by stirring tert-butyl 4-chloro-5,7-difluoro-3-methylquinolin-2-yl(pyridin-2-yl)carbamate (100 mg, 0.246 mmol), 4-(3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-6-yl)morpholine (57.5 mg, 0.246 mmol), Pd2dba3 (22.6 mg, 0.025 mmol), XPhos (23.5 mg, 0.049 mmol), sodium tert-butoxide (71.0 mg, 0.739 mmol), and toluene (2.5 mL) at 100° C. for 30 min. Purification by column chromatography on silica gel (0-60% EtOAc in hexanes) gave tert-butyl 4-(3,3-dimethyl-6-morpholino-2,3-dihydro-1H-pyrrolo[3,2-b]-pyridin-1-yl)-5,7-difluoro-3-methylquinolin-2-yl(pyridin-2-yl)carbamate. Mass Spectrum (ESI) m/e=603.2 (M+1).

Provenance & Evidence