HRID1618700
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Prepared according to procedure Y using 1-(4-bromo-5,7-difluoro-3-methylquinolin-2-yl)piperidin-2-one (45.0 mg, 0.130 mmol) and 6′-morpholino-1′,2,2′,3,5,6-hexahydrospiro[pyran-4,3′-pyrrolo[3,2-b]pyridine] in toluene to give 1-(5,7-difluoro-3-methyl-4-(6′-(4-morpholinyl)-2,3,5,6-tetrahydrospiro[pyran-4,3′-pyrrolo-[3,2-b]pyridin]-1′(2′H)-yl)-2-quinolinyl)-2-piperidinone. 1H NMR (400 MHz, chloroform-d) δ ppm 7.58 (1H, t, J=2.3 Hz), 7.55 (1H, d, J=9.4 Hz), 6.89-7.07 (1H, m), 5.55-6.01 (1H, m), 3.98-4.39 (4H, m), 3.46-3.93 (7H, m), 2.88-3.26 (4H, m), 2.54-2.72 (2H, m), 1.92-2.47 (8H, m), 1.61-1.90 (4H, m). Mass Spectrum (ESI) m/e=550.3 (M+1).
WORKUP
后处理
- customPrepared