Tetrahydrofuran → 4-Chloro-5,7-difluoro-3-methyl-2-(2-(methylsulfonyl)phenyl)quinoline

Participants

Reaction Steps

To a stirring solution of 4-chloro-5,7-difluoro-3-methyl-2-(2-(methylthio)phenyl)-quinoline (0.940 g, 2.80 mmol) in THF (20 mL) and water (6.7 mL) was added oxone (4.3 g, 7.00 mmol). The reaction was stirred at rt for 2 h, then 75 mL water was added and the mixture was stirred for 10 min. The resulting precipitate was isolated by filtration, then dissolved in EtOAc, dried over MgSO4, and concentrated to give 4-chloro-5,7-difluoro-3-methyl-2-(2-(methylsulfonyl)phenyl)-quinoline. Mass Spectrum (ESI) m/e=368.0 (M+1).

Provenance & Evidence