HCID 59631240, compound → HCID 49831209, compound

Participants

Reaction Steps

Prepared according to procedure Y using 4-chloro-5,7-difluoro-3-methyl-2-(5-methyl-2-(methylsulfonyl)phenyl)quinoline (60.0 mg, 0.160 mmol) and 4-(3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-6-yl)morpholine in toluene to give 4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-5,7-difluoro-3-methyl-2-(5-methyl-2-(methylsulfonyl)phenyl)quinoline. 1H NMR (400 MHz, chloroform-d) δ ppm 7.99-8.17 (1H, m), 7.43-7.64 (3H, m), 7.22-7.31 (1H, m), 7.07 (1H, ddd, J=11.9, 8.9, 2.4 Hz), 6.00 (1H, d, J=2.2 Hz), 4.03 (1H, d, J=9.0 Hz), 3.66-3.87 (4H, m), 3.61 (1H, d, J=8.8 Hz), 2.97-3.16 (7H, m), 2.52 (3H, s), 1.96 (3H, s), 1.42-1.60 (6H, m). Mass Spectrum (ESI) m/e=579.2 (M+1).

Provenance & Evidence