Potassium Carbonate → HCID 59631439, compound

Participants

Reaction Steps

Prepared according to procedure F by stirring 2,4-dichloro-5,7-difluoro-3-methylquinoline (0.5 g, 2.02 mmol), 2-methoxypyridin-4-ylboronic acid (0.31 g, 2.02 mmol), potassium carbonate (0.56 g, 4.03 mmol), Pd(PPh3)4 (0.23 g, 0.20 mmol), and toluene (4 mL) at 100° C. for 18 h. Purification by column chromatography (silica gel, 0-30% EtOAc in hexanes) gave 4-chloro-5,7-difluoro-2-(2-methoxypyridin-4-yl)-3-methylquinoline as an off-white solid. Mass Spectrum (ESI) m/e=321.1 (M+1).

Provenance & Evidence