HRID1618726
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Prepared according to procedure Y by using 4-(2,3-dihydro-1H-pyrido[2,3-b]-[1,4]thiazin-7-yl)morpholine (43.5 mg, 0.18 mmol), 4-chloro-7-fluoro-3-methyl-2-(pyridin-2-yl)quinoline (50 mg, 0.183 mmol), XPhos precatalyst (13.5 mg, 0.018 mmol) and sodium tert-butoxide (35.2 mg, 0.37 mmol) with heating in toluene (5 mL) for 1 h at 110° C. Purification by column chromatography (gradient of DCM to (DCM:MeOH:NH4OH, 90:9:1) from 1:0 to 9:1) gave 4-(1-(7-fluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazin-7-yl)morpholine. Mass Spectrum (ESI) m/e=474.0 (M+1).
WORKUP
后处理
- customPrepared
- customPurification by column chromatography (gradient of DCM to (DCM:MeOH:NH4OH, 90:9:1) from 1:0 to 9:1)