HRID1618728
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Prepared according to procedure Y by using 4-chloro-7-fluoro-3-methyl-2-(4-methylpyridin-2-yl)quinoline (54 mg, 0.19 mmol), 4-(2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazin-7-yl)morpholine (45 mg, 0.19 mmol), sodium tert-butoxide (36 mg, 0.38 mmol), XPhos precatalyst (14 mg, 0.019 mmol) in toluene (4 mL) for 1 h at 110° C. Purification by column chromatography (gradient of DCM to (DCM:MeOH:NH4OH, 90:9:1) from 1:0 to 8:2) gave 4-(1-(7-fluoro-3-methyl-2-(4-methylpyridin-2-yl)quinolin-4-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazin-7-yl)morpholine. Mass Spectrum (ESI) m/e=488.0 (M+1).
WORKUP
后处理
- customPrepared
- customfor 1 h
- customat 110° C
- customPurification by column chromatography (gradient of DCM to (DCM:MeOH:NH4OH, 90:9:1) from 1:0 to 8:2)