Morpholine → HCID 67284857, compound

Participants

Reaction Steps

Prepared according to procedure N by stirring tert-butyl 6-bromo-2′,3′,5′,6′-tetrahydrospiro[indole-3,4′-thiopyran]-1(2H)-carboxylate 1′,1′-dioxide (200 mg, 0.48 mmol), morpholine (62.8 μL, 0.721 mmol), sodium tert-butoxide, Pd2dba3 (44 mg, 0.048 mmol) and XPhos (45.8 mg, 0.096 mmol) in toluene (6 mL) at 100° C. for 2 h. Purification by column chromatography (hexanes:EtOAc, 1:0 to 1:1 as eluant) gave tert-butyl 6-(4-morpholinyl)-2′,3′,5′,6′-tetrahydrospiro[indole-3,4′-thiopyran]-1(2H)-carboxylate 1′,1′-dioxide. Mass Spectrum (ESI) m/e=423.0 (M+1).

Provenance & Evidence