HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 4-Chloro-2-(3-fluorophenyl)-3-methyl-1,8-naphthyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-Fluorophenylboronic acid | HCID 2733986 | — |
| Reactant | 2,4-Dichloro-3-methyl-1,8-naphthyridine | HCID 22082661 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 4-Chloro-2-(3-fluorophenyl)-3-methyl-1,8-naphthyridine | HCID 67285377 | — |
Reaction Steps
Prepared according to procedure F using 2,4-dichloro-3-methyl-1,8-naphthyridine (200 mg, 0.939 mmol), 3-fluorophenylboronic acid (131 mg, 0.939 mmol), sodium carbonate (199 mg, 1.877 mmol) and Pd(PPh3)4. Product used without further purification in the next step. Mass Spectrum (ESI) m/e=273.0 (M+1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765940B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-b8d5b396d55140e49e7bc3cd44c1704d |
| Source note | uspto-grants-2014_07 |