Reaction Steps
Prepared according to procedure Y using 1-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)azetidin-2-one (130 mg, 0.44 mmol) and 6′-morpholino-1′,2,2′,3,5,6-hexahydrospiro[pyran-4,3′-pyrrolo[3,2-b]pyridine] in toluene (except using cesium carbonate as base) to give 1-(5,7-difluoro-3-methyl-4-(6′-(4-morpholinyl)-2,3,5,6-tetrahydrospiro[pyran-4,3′-pyrrolo[3,2-b]pyridin]-1′(2′H)-yl)-2-quinolinyl)-2-azetidinone. 1H NMR (400 MHz, chloroform-d) δ ppm 7.59 (1H, d, J=2.3 Hz), 7.45 (1H, ddd, J=9.5, 2.4, 1.2 Hz), 6.89 (1H, ddd, J=11.8, 9.0, 2.4 Hz), 5.72 (1H, d, J=2.3 Hz), 4.13 (2H, m, J=11.6, 4.2, 4.0, 4.0 Hz), 4.00-4.09 (2H, m), 3.98 (1H, d, J=9.4 Hz), 3.85 (1H, d, J=9.4 Hz), 3.69-3.80 (4H, m), 3.57 (2H, m, J=11.7, 11.7, 2.9, 2.7 Hz), 3.16 (2H, t, J=5.0 Hz), 2.96-3.07 (4H, m), 2.39 (3H, s), 2.31 (2H, dddd, J=15.8, 8.9, 8.6, 4.5 Hz), 1.80 (1H, d, J=14.5 Hz), 1.67-1.75 (1H, m). Mass Spectrum (ESI) m/e=522.4 (M+1).
