HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 4-Chloro-2-(5-fluoropyridin-3-yl)-3-methyl-1,7-naphthyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | (5-Fluoropyridin-3-yl)boronic acid | HCID 44717403 | — |
| Reactant | 2,4-Dichloro-3-methyl-1,7-naphthyridine | HCID 59631549 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 4-Chloro-2-(5-fluoropyridin-3-yl)-3-methyl-1,7-naphthyridine | HCID 67285108 | — |
Reaction Steps
Prepared according to procedure F using 2,4-dichloro-3-methyl-1,7-naphthyridine (100 mg, 0.469 mmol), 5-fluoropyridine-3-boronic acid (66.1 mg, 0.469 mmol), sodium carbonate (87 mg, 0.821 mmol) and Pd(PPh3)4 (54.2 mg, 0.047 mmol). Product used without further purification in the next step. Mass Spectrum (ESI) m/e=274.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765940B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-876e54d216024e50824d4ace2eae4f6b |
| Source note | uspto-grants-2014_07 |