反应详情

温度

90 °C

Tert-Butyl-4-(3-Chloropropyl)-1-piperazine carboxylate and sodium-azide were dissolved (suspended) in 8 ml DMSO dry and heated to 90° C. for 15 h. The reaction mixture was allowed to cool to room temperature and pored into 50 ml of water. The product was extracted with DCM and the combined organic phases dried over MgSO4. The product was purified by flash column chromatography (n-heptane/ethylacetate 1:1, RF=0.34). Yield: 3.5 g.

1. customdry
2. temperatureto cool to room temperature
3. extractionThe product was extracted with DCM
4. dry with materialthe combined organic phases dried over MgSO4
5. customThe product was purified by flash column chromatography (n-heptane/ethylacetate 1:1, RF=0.34)