Dichloromethane → HCID 12974659, compound

Participants

Reaction Steps

234 mg of dansyl chloride (0.87 mmol) and 4.0 mL of anhydrous dichloromethane were placed in a 25 mL round-bottom flask equipped with a CaCl2 trap. 240 μL of triethylamine (1.73 mmol) and 330 μL of propargylamine (5.20 mmol) were added to the solution, which was then kept under stirring for 12 hours at room temperature. The residue obtained by distillation under reduced pressure was redissolved in some mL of tetrahydrofuran and the resulting mixture was filtrated. The evaporation of the solvent of the filtrated solution under reduced pressure affords the product in quantitative yield.

Provenance & Evidence