Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenacyl bromide | HCID 6259 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-Hydroxyquinoline | HCID 11376 | — |
| Reactant | 2,2,6,6-Tetramethyl-3,5-heptanedione | HCID 70700 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 68285598 | HCID 68285598 | 61.9% |
Reaction Steps
0.73 g of 3-quinolinol, 1.8 g of cesium carbonate, 0.18 g of dipivaloylmethane, 2.0 g of 2-bromoacetophenone, and 0.50 g of copper (I) chloride were dissolved in 10 ml of N-methylpyrrolidone, and the mixture was stirred for 3 hours at 130° C. The resultant was purified by silica gel column chromatography, and 0.82 g of 1-[2-(quinolin-3-yloxy)-phenyl]-ethanone (Compound Number 1) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08772200B2 |
|---|
| Source dataset | uspto-grants-2014_07 |
|---|
| ORD ID | ord-f9b356bc1e5741bcaf480b69f25b8bee |
|---|
| Source note | uspto-grants-2014_07 |
|---|
