Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 70968121 | HCID 70968121 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | HCID 68287962 | HCID 68287962 | — |
Reaction Steps
1.18 g of 2-chloro-6-(quinolin-3-yloxy)-benzonitrile was dissolved in 5 ml of 80% sulfuric acid and the mixture was stirred for 3 hours at 100° C. After being neutralized with an aqueous solution of sodium hydroxide, the liquid was separated with ethyl acetate, the organic layer was concentrated and 1.03 g of 2-chloro-6-(quinolin-3-yloxy)-benzamide (Compound Number 20) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08772200B2 |
|---|
| Source dataset | uspto-grants-2014_07 |
|---|
| ORD ID | ord-22f3aeadcb22441facd1bfbf998c9649 |
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| Source note | uspto-grants-2014_07 |
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