HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 68288280, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,3-Difluoro-2-iodobenzene | HCID 2782738 | — |
| Reactant | 8-fluoroquinolin-3-ol | HCID 68288067 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 68288280 | HCID 68288280 | 22.1% |
Reaction Conditions
| Temperature | 130 °C |
|---|
Reaction Steps
16 ml of N-methylpyrrolidone was added to 1.06 g of 8-fluoro-3-hydroxyquinoline, 1.94 g of 2,6-difluoroiodobenzene, and 1.7 g of potassium carbonate, and the mixture was stirred for 24 hours at 130° C. The reaction solution was purified by silica gel column chromatography, and 0.55 g of 8-fluoro-3-(3-fluoro-2-iodophenoxy)-quinoline was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772200B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-2fae9f307b6a449c9c0aa0b82ab1033c |
| Source note | uspto-grants-2014_07 |