Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 68288281 | HCID 68288281 | — |
| Reactant | HCID 178418332 | HCID 178418332 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 68289360 | HCID 68289360 | — |
Reaction Steps
After 0.64 g of 1-[2-(7,8-difluoroquinolin-3-yloxy)-6-fluoro-phenyl]-ethanone was dissolved in 10 ml of tetrahydrofuran, the resultant was cooled to 0° C. and 1.5 ml of methylmagnesium chloride (3.0 M tetrahydrofuran solution) was added dropwise. Dilute hydrochloric acid was added to the reaction solution, and the liquid was separated with ethyl acetate. The organic layer was concentrated and purified by silica gel column chromatography to obtain 0.49 g of 2-[2-(7,8-difluoroquinolin-3-yloxy)-6-fluoro-phenyl]-propan-2-ol (Compound Number 124).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08772200B2 |
|---|
| Source dataset | uspto-grants-2014_07 |
|---|
| ORD ID | ord-687935198750430182752a4e90705a5e |
|---|
| Source note | uspto-grants-2014_07 |
|---|
