Hydrochloric Acid → HCID 68288281, compound

Participants

Reaction Conditions

Reaction Steps

0.5 g of 7,8-difluoro-3-hydroxyquinoline was dissolved in 10 mL of dimethylformamide. 0.52 g of 2,6-difluoroacetophenone and 0.46 g of potassium carbonate were added to the solution, and the mixture was stirred for 2.5 hours at 100° C. The thus obtained reaction solution was poured into ice water and then neutralized with dilute hydrochloric acid, the liquid was separated with ethyl acetate. The organic layer was concentrated and purified by silica gel column chromatography to obtain 0.38 g of 1-[2-fluoro-6-(7,8-difluoroquinolin-3-yloxy)-phenyl]-ethanone (Compound Number 391).

Provenance & Evidence