Water → HCID 86663090, compound

HRID 1618923Notes

Reaction equation

HRID 1618923 reaction equation
P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:2].[CH:15]1([N:18]([CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[Si:38]([CH3:41])([CH3:40])[CH3:39])[C:19]([C:21]2[C:22]([CH:28]([F:30])[F:29])=[N:23][N:24]([CH3:27])[C:25]=2[F:26])=O)[CH2:17][CH2:16]1.O>O1CCOCC1>[CH:15]1([N:18]([CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[Si:38]([CH3:41])([CH3:40])[CH3:39])[C:19]([C:21]2[C:22]([CH:28]([F:30])[F:29])=[N:23][N:24]([CH3:27])[C:25]=2[F:26])=[S:2])[CH2:17][CH2:16]1

Participants

5

Reactant 3

HCID 962WaterHCID 14817Phosphorus sulfide (P2S5)HCID 66686510HCID 66686510, compound

Product 1

HCID 86663090HCID 86663090, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

A solution of 140 mg (0.31 mmol) of phosphorus pentasulfide and 500 mg (1.26 mmol) of N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-N-[2-(trimethylsilyl)benzyl]-1H-pyrazole-4-carboxamide in 20 ml of dioxane was heated at 100° C. for 2.5 hours. 2 ml of water were then added and the reaction mixture was heated at 100° C. for another 1 hour.

Sources & evidence

ORD record
ord-9c6664614359498b86b15e23a945d076
Source dataset
uspto-grants-2014_07
Patent number
US08772266B2

Reaction notes

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