反应详情

1-(2,2-Dimethylpropyl)-5-nitro-1H-1,2,3-benzotriazole (4.46 g, 19.0 mmol, 1.0 equiv.) was dissolved in ethanol (50 ml), sparged under nitrogen, charged with 10% Pd/C (2.03 g, 1.90 mmol, 0.1 equiv.) and then sparged under hydrogen (1 atm). After stirring at room temperature for 5 hrs, the mixture was filtered through Celite and the residue was washed with MeOH. The filtrate was concentrated in vacuo to provide the titled compound. LRMS m/z (M+H) 205.0 found, 205.3 required.

1. customsparged under nitrogen
2. customsparged under hydrogen (1 atm)
3. filtrationthe mixture was filtered through Celite
4. washthe residue was washed with MeOH
5. concentrationThe filtrate was concentrated in vacuo