Benzo[b]furan-2-boronic acid → HCID 68314535, compound

HRID 1618963Notes

Reaction equation

HRID 1618963 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[NH:16][C:15]3[C:14]4([O:21][CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17]4)[CH2:13][N:12](CC4C=CC(OC)=CC=4)[C:11](=[O:38])[C:10]=3[CH:9]=2)[CH:5]=[CH:4][N:3]=1.[O:39]1[C:43]2[CH:44]=[CH:45][CH:46]=[CH:47][C:42]=2[CH:41]=[C:40]1B(O)O>>[O:39]1[C:43]2[CH:44]=[CH:45][CH:46]=[CH:47][C:42]=2[CH:41]=[C:40]1[C:2]1[N:7]=[C:6]([C:8]2[NH:16][C:15]3[C:14]4([O:21][CH2:20][CH2:19][NH:18][CH2:17]4)[CH2:13][NH:12][C:11](=[O:38])[C:10]=3[CH:9]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 2776266Benzo[b]furan-2-boronic acidHCID 86762494HCID 86762494, compound

Product 1

HCID 68314535HCID 68314535, compound

Procedure

The title compound was prepared following the general procedure reported for Example 1—1 using E8 and 2-benzofuraneboronic acid. The crude was purified by semi-preparative HPLC (method A) and isolated as a TFA-salt. MS (ES) C22H19N5O3 requires: 401. found: 402.1[M+H]+.

Workup

  1. customThe crude was purified by semi-preparative HPLC (method A)

Sources & evidence

ORD record
ord-a9b5d5de4cb942198e0e7c51409ab6a2
Source dataset
uspto-grants-2014_07
Patent number
US08772286B2

Reaction notes

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