HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → N-[(1-Butyl-4-piperidinyl)methyl]5-chloro-2-methylbenzoxazole-7-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-Aminomethyl-1-N-butylpiperidine | HCID 10442133 | — |
| Reactant | 5-Chloro-2-methylbenzoxazole-7-carboxylic acid | HCID 19691864 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | N-[(1-Butyl-4-piperidinyl)methyl]5-chloro-2-methylbenzoxazole-7-carboxamide | HCID 19691850 | — |
Reaction Steps
5-Chloro-2-methylbenzoxazole-7-carboxylic acid (Ger. Offen. 2,225,544) is converted to its acid chloride by treatment with oxalyl chloride. The acid chloride is treated with N-(1-butyl-4-piperidinyl)methylamine in the presence of triethylamine to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05726187 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-6d542e3dbdd248a898a4ea74dbd0c2eb |
| Source note | uspto-grants-1998_03 |